S.J. van Norden (Suzanne)

During my PhD, I am working on the PREDYct study (PRedicting Efficacy of neuromoDulation in epilepsY).

Vagus nerve stimulation (VNS) can offer therapeutic benefits to patients with pharmacoresistant epilepsy who are not eligible for surgical treatment. However, its effectiveness varies significantly: approximately one-third of patients respond well, one-third experience limited benefit, and one-third show no improvement. Currently, we lack reliable methods to predict which patients will benefit from VNS and to what extent.

The PREDYct study aims to identify biomarkers that can predict the efficacy of VNS in individual patients. To achieve this, candidates for VNS therapy are first implanted with a subcutaneous EEG (sqEEG) electrode approximately two months prior to VNS implantation. This allows for baseline monitoring. sqEEG recordings are then continued for up to fifteen months after VNS implantation, enabling comprehensive assessment of treatment effects over time.

For more information, visit www.predyct.nl

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University of Twente

Technohal (building no. 18), room 3385
Hallenweg 5
7522 NH Enschede
Netherlands

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