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prof.dr.ir. S. Le Gac (Severine)

Full Professor

About Me

Séverine Le Gac received her Engineer degree in chemistry (specialization biology) from the ESPCI (Paris, France) and her DEA (MSc equivalent; interface biology/chemistry) from the MNHN (Paris, France) in 2000. In 2004, she obtained her PhD degree cum laude in life sciences from the university of Lille 1 (Lille, France) for the development of microfluidic systems for proteomic analysis by mass spectrometry. For this work she conducted in the group of Dr. Rolando, she was attributed the PhD prize of the French Society for Mass Spectrometry in 2005. After a 2-months stay in the lab of Prof. Baba in Japan, she started as a post-doctoral fellow at the University of Twente, at the MESA+ Institute for Nanotechnology and the BIOS, Lab-on-a-Chip Group under the supervision of Prof. van den Berg. After a 3-year post-doctoral stay, she was offered a tenure-track position (assistant professor) in the same group and the same institute. In 2012, she was appointed Program Director for the topic “Innovative Nanotechnology for Medicine” at the MESA+ Institute for Nanotechnology and in 2013, she obtained tenure.

Currently, Dr. Le Gac is an Adjunct Professor at the University of Twente (The Netherlands) and she is leading a team called “Applied Microfluidics for BioEngineering Research – AMBER” which is part of the MESA+ Institute for Nanotechnology and the TechMed Institute. She is Associate Editor of the peer-reviewed journal Biomedical Microdevices (Springer Publishing Group), part of the advisory board of the Journal of Micromechanics and Microengineering (IOP Published) and of the editorial board of the open-access journal Micromachines (mdpi). Since 2018, she has also been Member of the Director Board of the CBMS Society (Chemical and Biological Microsystem Society).

Her research interests focus on the use of microfluidic devices for biological and medical applications, including experimentation on cell membrane models and ion channels, single cell analysis, organ-on-a-chip platform, and assisted reproductive technologies.

For more information, please visit http://www.severinelegac.com/.

Expertise

Engineering & Materials Science
Microfluidics
Regenerative Medicine
Tissue
Tumors
Medicine & Life Sciences
Lab-On-A-Chip Devices
Lipid Bilayers
Microfluidics
Chemistry
Communication

Ancillary Activities

  • CBMS (Chemical and Biological Microsystems Society)
    President of the non-profit organization CBMS (Chemical and Biological Microsystems Society)

Publications

Recent
Bertelink, S., Laffont, L., Grasseau, I., Reynaud, K., Saint-Dizier, M., Venzac, B. , & Le Gac, S. (2023). STUDYING AND IMPROVING THE CYTOCOMPATIBILITY OF SLA RESINS. Poster session presented at 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2023, Katowice, Poland.
Bertelink, S., Laffont, L., Grasseau, I., Reynaud, K., Saint-Dizier, M., Venzac, B. , & Le Gac, S. (2023). STUDYING AND IMPROVING THE CYTOCOMPATIBILITY OF SLA RESINS. Poster session presented at NanoBioTech Montreux 2023, Montreux, Switzerland.
Mol, L. , Pondman, K., Staal, Y. , & Le Gac, S. (2023). Developing a lung-on-chip device for studying the impact of micro- and nanoplastics on human lung tissue. Poster session presented at NanoBioTech Montreux 2023, Montreux, Switzerland.
Devamoglu, U. , & Le Gac, S. (2023). Re-creating the vasculopathy observed in fibrotic diseases and systemic sclerosis. Poster session presented at NanoBioTech Montreux 2023, Montreux, Switzerland.
Na, Y., Devamoglu, U. , Le Gac, S., & Paez, J. (2023). Improving interfacial adhesion of hydrogel matrices to PDMS-based microfluidic platforms. Poster session presented at TechMed Research Day 2023, Enschede, Netherlands.
Na, Y., Devamoglu, U. , Le Gac, S., & Paez, J. (2023). Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms. Poster session presented at 32nd NBTE Annual Meeting 2023, Lunteren, Netherlands.
Na, Y., Devamoglu, U. , Le Gac, S., & Paez, J. (2023). Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms. Poster session presented at 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2023, Katowice, Poland.
Na, Y., Devamoglu, U. , Le Gac, S., & Paez, J. (2023). Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms. Poster session presented at NanoBioTech Montreux 2023, Montreux, Switzerland.
Spoelstra, L. R. , Araújo-Gomes, N., Zakharova - Kolezhuk, M., Welting, T. J. M. , Karperien, M. , Segerink, L. , & Le Gac, S. (2023). Development of a Synovium-on-Chip Model with a Porous Membrane to Study Inflammatory Arthritis. Poster session presented at NanoBioTech Montreux 2023, Montreux, Switzerland.
Faber, B., Noll, M. , Le Gac, S. , & Pondman, K. (2023). Elucidating the role of circulating tumor microemboli (CTM): applying organ-on-chip technology and in vitro models of homo- and heterotypic CTM. Poster session presented at 6th Advances in Circulating Tumor Cells, ACTC 2023, Skiathos, Greece.

UT Research Information System

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Contact Details

Visiting Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Horst Complex (building no. 20), room ZH135
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Horst Complex  ZH135
P.O. Box 217
7500 AE Enschede
The Netherlands