Horst Complex

prof.dr.ir. S. Le Gac (Severine)

Full Professor
EEMCS-EE-AMBER
Horst Complex ZH135
s.legac@utwente.nl
+31534892722
Business card

SĆ©verine Le Gac received her Engineer degree in chemistry (specialization biology) from the ESPCI (Paris, France) and her DEA (MSc equivalent; interface biology/chemistry) from the MNHN (Paris, France) in 2000. In 2004, she obtained her PhD degree cum laude in life sciences from the University of LilleĀ (Lille, France) for the development of microfluidic systems for proteomic analysis by mass spectrometry. For this work she conducted in the group of Dr. Rolando, she was attributed the PhD prize of the French Society for Mass Spectrometry in 2005. After a 2-months stay in the lab of Prof. Yoshinobu Baba in Japan, she started as a post-doctoral fellow at the University of Twente, at the MESA+ Institute for Nanotechnology and the BIOS, Lab-on-a-Chip Group under the supervision of Prof. Albert van den Berg. After a 3-year post-doctoral stay, she was offered a tenure-track position (assistant professor) in the same group and the same institute. In 2012, she was appointed Program Director for the topic ā€œInnovative Nanotechnology for Medicineā€ at the MESA+ Institute for Nanotechnology and in 2013, she obtained tenure.

Currently, Dr. Le Gac is a Full Professor at the University of Twente (The Netherlands) and she is leading a team called ā€œApplied Microfluidics for BioEngineering Research ā€“ AMBERā€ which is part of the MESA+ Institute for Nanotechnology and the TechMed Institute. She is Associate Editor of the peer-reviewed journal Lab on a Chip (RSC) and president ofĀ the Director Board of the CBMS Society (Chemical and Biological Microsystems Society). She was chairingĀ MicroTAS, 2020 with Prof. Hang Lu (GeorgiaTech).

Her research interests focus on the use of microfluidic devices for biological and medical applications, for biomarker analysis and the development of organ-on-a-chip platforms with a particular focus onĀ disease modeling (cancer, fibrotic diseases) and the field of medically assisted reproduction.

For more information, please visit http://www.severinelegac.com/.

Expertise

  • Chemistry

    • Microfluidics
    • Device
    • Concentration
    • Dioxygen

  • Medicine and Dentistry

    • Culture
    • Cells

  • Biochemistry, Genetics and Molecular Biology

    • Development
    • Lipid Bilayer

Organisations

Ancillary activities

  • Royal Society of ChemistryAssociate Editor for the Lab on a Chip journal
  • CBMS (Chemical and Biological Microsystems Society)President of the non-profit organization CBMS (Chemical and Biological Microsystems Society)

Publications

2023

Development of a Synovium-on-Chip Model with a Porous Membrane to Study Inflammatory Arthritis (2023)[Contribution to conference › Poster] NanoBioTech Montreux 2023. Spoelstra, L. R., Araújo-Gomes, N., Zakharova - Kolezhuk, M., Welting, T. J. M., Karperien, M., Segerink, L. & Le Gac, S.Developing a lung-on-chip device for studying the impact of micro- and nanoplastics on human lung tissue (2023)[Contribution to conference › Poster] NanoBioTech Montreux 2023. Mol, L., Pondman, K., Staal, Y. & Le Gac, S.STUDYING AND IMPROVING THE CYTOCOMPATIBILITY OF SLA RESINS (2023)[Contribution to conference › Poster] NanoBioTech Montreux 2023. Bertelink, S., Laffont, L., Grasseau, I., Reynaud, K., Saint-Dizier, M., Venzac, B. & Le Gac, S.STUDYING AND IMPROVING THE CYTOCOMPATIBILITY OF SLA RESINS (2023)[Contribution to conference › Poster] 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2023. Bertelink, S., Laffont, L., Grasseau, I., Reynaud, K., Saint-Dizier, M., Venzac, B. & Le Gac, S.Elucidating the role of circulating tumor microemboli (CTM): applying organ-on-chip technology and in vitro models of homo- and heterotypic CTM (2023)[Contribution to conference › Poster] 6th Advances in Circulating Tumor Cells, ACTC 2023. Faber, B., Noll, M., Le Gac, S. & Pondman, K.Evaluation of paclitaxel-loaded polymeric nanoparticles in 3D tumor model: impact of tumor stroma on penetration and efficacy (2023)Drug delivery and translational research, 13(5), 1470-1483. Priwitaningrum, D. L., Pednekar, K., Gabriël, A. V., Varela-Moreira, A. A., Gac, S. L., Vellekoop, I., Storm, G., Hennink, W. E. & Prakash, J.https://doi.org/10.1007/s13346-023-01310-1Single-molecule super-resolution imaging of microfabricated 3D substrates for 3D cell culture (Conference Presentation) (2023)[Contribution to conference › Other] SPIE BiOS 2023. Cabriel, C., Córdova-Castro, M., Berenschot, E., Dávila-Lezema, A., Pondman, K., Gac, S. L., Tas, N., Susarrey-Arce, A. & Izeddin, I.https://doi.org/10.1117/12.2648989Nanoparticle-induced immune response: Health risk versus treatment opportunity? (2023)Immunobiology, 228(2). Article 152317. Pondman, K., le Gac, S. & Kishore, U.https://doi.org/10.1016/j.imbio.2022.152317Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms (2023)[Contribution to conference › Poster] 32nd NBTE Annual Meeting 2023. Na, Y., Devamoglu, U., Le Gac, S. & Paez, J.Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms (2023)[Contribution to conference › Poster] 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2023. Na, Y., Devamoglu, U., Le Gac, S. & Paez, J.

Research profiles

Affiliated study programs

Courses academic year 2024/2025

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2023/2024

Address

University of Twente

Horst Complex (building no. 20), room ZH135
De Horst 2
7522 LW Enschede
Netherlands

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