prof.dr.ir. S. le Gac (Severine)

Full Professor

About Me

Séverine Le Gac received her Engineer degree in chemistry (specialization biology) from the ESPCI (Paris, France) and her DEA (MSc equivalent; interface biology/chemistry) from the MNHN (Paris, France) in 2000. In 2004, she obtained her PhD degree cum laude in life sciences from the university of Lille 1 (Lille, France) for the development of microfluidic systems for proteomic analysis by mass spectrometry. For this work she conducted in the group of Dr. Rolando, she was attributed the PhD prize of the French Society for Mass Spectrometry in 2005. After a 2-months stay in the lab of Prof. Baba in Japan, she started as a post-doctoral fellow at the University of Twente, at the MESA+ Institute for Nanotechnology and the BIOS, Lab-on-a-Chip Group under the supervision of Prof. van den Berg. After a 3-year post-doctoral stay, she was offered a tenure-track position (assistant professor) in the same group and the same institute. In 2012, she was appointed Program Director for the topic “Innovative Nanotechnology for Medicine” at the MESA+ Institute for Nanotechnology and in 2013, she obtained tenure.

Currently, Dr. Le Gac is an Adjunct Professor at the University of Twente (The Netherlands) and she is leading a team called “Applied Microfluidics for BioEngineering Research – AMBER” which is part of the MESA+ Institute for Nanotechnology and the TechMed Institute. She is Associate Editor of the peer-reviewed journal Biomedical Microdevices (Springer Publishing Group), part of the advisory board of the Journal of Micromechanics and Microengineering (IOP Published) and of the editorial board of the open-access journal Micromachines (mdpi). Since 2018, she has also been Member of the Director Board of the CBMS Society (Chemical and Biological Microsystem Society).

Her research interests focus on the use of microfluidic devices for biological and medical applications, including experimentation on cell membrane models and ion channels, single cell analysis, organ-on-a-chip platform, and assisted reproductive technologies.

For more information, please visit http://www.severinelegac.com/.


Engineering & Materials Science
Regenerative Medicine
Medicine & Life Sciences
Lab-On-A-Chip Devices
Lipid Bilayers


Palacio-Castaneda, V., Velthuijs, N. , Le Gac, S., & Verdurmen, W. P. R. (2022). Oxygen control: the often overlooked but essential piece to create better in vitro systems. Lab on a chip, 22, 1068-1092. https://doi.org/10.1039/d1lc00603g
Picollet-D'hahan, N. , Zuchowska, A., Lemeunier, I. , & Le Gac, S. (2021). Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication. Trends in biotechnology, 39(8), 788-810. https://doi.org/10.1016/j.tibtech.2020.11.014
Venzac, B., Deng, S., Mahmoud, Z. , Lenferink, A., Costa, A., Bray, F. , Otto, C., Rolando, C. , & Le Gac, S. (2021). PDMS Curing Inhibition on 3D-Printed Molds: Why? Also, How to Avoid It? Analytical chemistry, 93(19), 7180-7187. https://doi.org/10.1021/acs.analchem.0c04944

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Visiting Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Horst Complex (building no. 20), room ZH135
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Electrical Engineering, Mathematics and Computer Science
Horst Complex  ZH135
P.O. Box 217
7500 AE Enschede
The Netherlands