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S. le Gac (Severine)

Associate Professor

About Me

Séverine Le Gac received her Engineer degree in chemistry (specialization biology) from the ESPCI (Paris, France) and her DEA (MSc equivalent; interface biology/chemistry) from the MNHN (Paris, France) in 2000. In 2004, she obtained her PhD degree cum laude in life sciences from the university of Lille 1 (Lille, France) for the development of microfluidic systems for proteomic analysis by mass spectrometry. For this work she conducted in the group of Dr. Rolando, she was attributed the PhD prize of the French Society for Mass Spectrometry in 2005. After a 2-months stay in the lab of Prof. Baba in Japan, she started as a post-doctoral fellow at the University of Twente, at the MESA+ Institute for Nanotechnology and the BIOS, Lab-on-a-Chip Group under the supervision of Prof. van den Berg. After a 3-year post-doctoral stay, she was offered a tenure-track position (assistant professor) in the same group and the same institute. In 2012, she was appointed Program Director for the topic “Innovative Nanotechnology for Medicine” at the MESA+ Institute for Nanotechnology and in 2013, she obtained tenure.

Currently, Dr. Le Gac is an Associate Professor at the University of Twente (The Netherlands) and she is leading a team called “Applied Microfluidics for BioEngineering Research – AMBER” which is part of the MESA+ Institute for Nanotechnology and the TechMed Institute. She is also Associate Editor of the peer-reviewed journal Biomedical Microdevices (Springer Publishing Group). She is also Member of the Director Board of the CBMS Society (Chemical and Biological Microsystem Society).

Her research interests focus on the use of microfluidic devices for biological and medical applications, including experimentation on cell membrane models and ion channels, single cell analysis, organ-on-a-chip platform, and assisted reproductive technologies.

For more information, please visit http://www.severinelegac.com/.

Expertise

Microfluidics
Neoplasms
Lab-On-A-Chip Devices
Cells
Polymers
Microfluidics
Microfluidics
Imaging Techniques

Publications

Recent
le Gac, S., & Van Uitert, I. (2018). Electroporation in Microfluidic devices. In D. Miklavčič (Ed.), Handbook of electroporation Springer. DOI: 10.1007/978-3-319-26779-1
de Almeida Monteiro Melo Ferraz, M., Henning, H. H. W., Ferreira da Costa, P., Malda, J., le Gac, S., Bray, F., ... Gadella, B. M. (2018). Potential Health and Environmental Risks of Three-Dimensional Engineered Polymers. Environmental Technology Letters, 5(2), 80-85. DOI: 10.1021/acs.estlett.7b00495
le Gac, S., Venzac, B., Rho, H. S., Ferraz, M., Henning, H., Pinheiro, N., ... Stout, T. (2017). Mimicking the bovine oviduct in a microfluidic platform for embryo in vitro production and in vitro culture. Poster session presented at NanoBioTech Montreux 2017, Montreux, Switzerland.
le Gac, S., Abbas, Y., van Rossem, F., & Bomer, J. G. (2017). Monitoring the respiratory activity of multicellular tumor spheroids in an integrated microfluidic device. Paper presented at 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017, Savannah, United States.
le Gac, S. (2017). Microfluidic Platform for Parallel Single Cell Analysis for Diagnostic Applications. In V. Taly, S. Descroix, & J-L. Viovy (Eds.), Microchip Diagnostics (pp. 187-209). (Methods in Molecular Biology; Vol. 1547). Springer Science+Business Media. DOI: 10.1007/978-1-4939-6734-6_15
Ripken, R. M., Gardeniers, H., & le Gac, S. (2017). Real-time monitoring of complex multiphase behavior in a high pressure and high temperature microfluidic chip. Poster session presented at 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017, Savannah, United States.

UT Research Information System

Contact Details

Visiting Address

University of Twente
Faculty of Electrical Engineering, Mathematics & Computer Science
Horst Complex (building no. 20), room ZH112
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Electrical Engineering, Mathematics & Computer Science
Horst Complex  ZH112
P.O. Box 217
7500 AE Enschede
The Netherlands