dr.ir. S. Lindhoud | People Pages: Find employees & contact details

Biological processes are extremely efficient. My research is inspired by separation processes used in the cell. The cellular fluid is highly organised. This organisation occurs via aqueous liquid-liquid phase separation of molecules and can be mimicked by polyion condensation. These dense phases can very selectively take up molecules. This concept can be used for separation processes in industry, beter understanding of protein accumulation in biological condensates and the accumulation of functional molecules in relation to the Origin of Life.

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Saskia Lindhoud is the webmaster and newsletter editor of the IACIS

Expertise

Material Science
- Polyelectrolyte
- Temperature
Biochemistry, Genetics and Molecular Biology
- Protein
- Membrane
- Synuclein
Chemistry
- Structure
- Micelle
- Reaction Temperature

Organisations

After completing a BSc and MSc on Molecular Sciences at Wageningen University in 2005, I started a PhD project at the Laboratory of Physical Chemistry and Colloid Science under supervision of Prof. Martien Cohen Stuart and Prof. Willem Norde. The topic of my PhD work was the incorporation of enzymes in polyelectrolyte complex micelles. Within four years (2009) I defended my thesis entitled “Polyelectrolyte Complex Micelles as Wrapping for Enzymes.” After graduating, I left the Netherlands to investigate whether shower-gel can be made “greener” using oxidized cellulose as viscosity modifier. This research was performed at the University of Bath (UK). During this two year project I performed many neutron and x-ray scattering experiments at large scale facilities (ISIS, DIAMOND, ESRF and ILL) trying to resolve the structure of these oxidized cellulose gels. Beginning 2013 I joined the Nanobiophysics group at the University of Twente to work on a project called: “Motor failure in cellular disease.” Later that year I was awarded NWO prestigious Veni award on “Complex Coacervates as Molecular Crowding Agents,” to start my own research line. In June 2016 I became an Assistant Professor at the Nanobiophysics group. In April 2020 I joined the Molecular Nanofabrication group to continue my research and teaching at the University of Twente.

Publications

2023

Conceptual Modeling Enables Systems Thinking in Sustainable Chemistry and Chemical Engineering, 4577-4584. Krab - Hüsken, L. E., Pei, L., de Vries, P. G., Lindhoud, S., Paulusse, J. M. J., Jonkheijm, P. & Wong, A. S. Y.https://doi.org/10.1021/acs.jchemed.3c00337Control over Charge Density by Tuning the Polyelectrolyte Type and Monomer Ratio in Saloplastic-Based Ion-Exchange Membranes, 6874-6884. Krishna B, A., de Vos, W. M. & Lindhoud, S.https://doi.org/10.1021/acs.langmuir.3c00497Preparation of Sodium Carboxymethyl Cellulose-Chitosan Complex Membranes through Sustainable Aqueous Phase Separation, 1810-1818. Li, L., Baig, M. I., de Vos, W. M. & Lindhoud, S.https://doi.org/10.1021/acsapm.2c01901

2022

Biomolecular condensates can both accelerate and suppress aggregation of α-synuclein, Article eabq6495. Lipiński, W. P., Visser, B. S., Robu, I., Fakhree, M. A. A., Lindhoud, S., Claessens, M. M. A. E. & Spruijt, E.https://doi.org/10.1126/sciadv.abq6495Hot-pressed Saloplastics as Sustainable Ion-exchange Membranes. University of Twente. Krishna B, A.https://doi.org/10.3990/1.9789036554084Biocatalytic membranes through aqueous phase separation, 903-910. van Lente, J. J., Baig, M. I., de Vos, W. M. & Lindhoud, S.https://doi.org/10.1016/j.jcis.2022.02.094Sustainable K⁺/Na⁺ monovalent-selective membranes with hot-pressed PSS-PVA saloplastics, Article 120463. Krishna B, A., Zwijnenberg, H. J., Lindhoud, S. & de Vos, W. M.https://doi.org/10.1016/j.memsci.2022.120463Applications of Polyelectrolyte Complexes for Separation Processes. University of Twente. van Lente, J. J.https://doi.org/10.3990/1.9789036553025Hot-pressing polyelectrolyte complexes into tunable dense saloplastics, Article 124583. Krishna B, A., Willott, J. D., Lindhoud, S. & de Vos, W. M.https://doi.org/10.1016/j.polymer.2022.124583Extraction of Lysozyme from Chicken Albumen Using Polyelectrolyte Complexes, Article 2105147. van Lente, J. J. & Lindhoud, S.https://doi.org/10.1002/smll.202105147

Research profiles

Affiliated study programs

Courses academic year 2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.