Welcome...

dr.ir. S. Lindhoud (Saskia)

Assistant Professor

About Me

Complex coacervate droplets: from life to death and how to turn it into technology?

Complex coacervates are dense liquid-like phases that form when oppositely charged macro-ions are mixed under the right conditions (pH, ionic strength, mixing ratio). 

My research focusses on three different aspects of these complex coacervates: 

Droplets of Life
I believe that inside complex coacervates containing RNA and polycations proteins can be formed from amino acids without the presence of enzymes and DNA. These droplets will allow me to provide direct evidence for the RNA world hypothesis, but understanding the mechanism is equally if not more important.

Droplets of Death
In many cases membrane-less organelles are part of a disease pathway. Proteins which accumulate inside the droplets form fibrils that are lethal for the cell. If we can predict under what conditions disease related proteins bind and accumulate, this may lead to new ways to interupt the disease pathway.

Droplets for Tech
The fundamental questions that are being investigated in the Droplets of Life and Droplets of Death pillars of my research will lead to new applications of complex coacervate droplets. 

 

 

Expertise

Micelles
Proteins
Enzymes
Molecules
Salts
Lipases
Homopolymerization
Polyelectrolytes

Publications

Recent Articles
Lindhoud, S., & Claessens, M. M. A. E. (2013). Motor failure in neurodegenerative disease. -. Poster session presented at NanoNextNL Bionano theme day, Utrecht, .
Semerdzhiev, S. A., Dekker, D. R., Lindhoud, S., Subramaniam, V., & Claessens, M. M. A. E. (2013). Hierarchical self-assembly of alpha-synuclein. -. Poster session presented at International Soft Matter Conference, Rome, Italy, .
Semerdzhiev, S. A., Dekker, D. R., Lindhoud, S., Subramaniam, V., & Claessens, M. M. A. E. (2013). Hierarchical self-assembly of alpha-synuclein. -. Poster session presented at International Soft Matter Conference, Rome, Italy, .
Lindhoud, S., & Cohen Stuart, M. A. (2013). Relaxation phenomena during polyelectrolyte complex formation. In M. Mueller (Ed.), Polyelectrolyte Complexes in the Dispersed and Solid State I, Principles and Theory (pp. 139-172)
Crawford, R. J., Edler, K. J., Lindhoud, S., Scott, J. L., & Unali, G. (2012). Formation of shear thinning gels from partially oxidised cellulose nanofibrils. Green chemistry, 14(2), 300-303. DOI: 10.1039/C2GC16302K

UT Research Information System

Google Scholar Link

Affiliated Study Programmes

Bachelor

Projects

Below you can find a selection of MSc and BSc projects.

Please drop me an email if you are interested s.lindhoud@utwente.nl

 

 

Current Projects

Contact Details

Visiting Address

University of Twente
Faculty of Science and Technology
Horst - Zuidhorst (building no. 28), room 157
De Horst 2
7522LW  Enschede
The Netherlands

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Mailing Address

University of Twente
Faculty of Science and Technology
Horst - Zuidhorst  157
P.O. Box 217
7500 AE Enschede
The Netherlands

Working days

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