dr.ir. S. Lindhoud (Saskia)

Biological processes are extremely efficient. My research is inspired by separation processes used in the cell. The cellular fluid is highly organised. This organisation occurs via aqueous liquid-liquid phase separation of molecules and can be mimicked by polyion condensation. These dense phases can very selectively take up molecules. This concept can be used for separation processes in industry, beter understanding of protein accumulation in biological condensates and the accumulation of functional molecules in relation to the Origin of Life.

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Saskia Lindhoud is the webmaster and newsletter editor of the IACIS

Engineering & Materials Science

# Enzymes
# Membranes
# Micelles
# Polyelectrolytes
# Proteins
# Salts

Physics & Astronomy

# Micelles

Chemistry

# Micelle

Faculty of Science and Technology (TNW), Molecular Nanofabrication (MNF)

After completing a BSc and MSc on Molecular Sciences at Wageningen University in 2005, I started a PhD project at the Laboratory of Physical Chemistry and Colloid Science under supervision of Prof. Martien Cohen Stuart and Prof. Willem Norde. The topic of my PhD work was the incorporation of enzymes in polyelectrolyte complex micelles. Within four years (2009) I defended my thesis entitled “Polyelectrolyte Complex Micelles as Wrapping for Enzymes.” After graduating, I left the Netherlands to investigate whether shower-gel can be made “greener” using oxidized cellulose as viscosity modifier. This research was performed at the University of Bath (UK). During this two year project I performed many neutron and x-ray scattering experiments at large scale facilities (ISIS, DIAMOND, ESRF and ILL) trying to resolve the structure of these oxidized cellulose gels. Beginning 2013 I joined the Nanobiophysics group at the University of Twente to work on a project called: “Motor failure in cellular disease.” Later that year I was awarded NWO prestigious Veni award on “Complex Coacervates as Molecular Crowding Agents,” to start my own research line. In June 2016 I became an Assistant Professor at the Nanobiophysics group. In April 2020 I joined the Molecular Nanofabrication group to continue my research and teaching at the University of Twente.

Krab - Hüsken, L. E. , Pei, L., de Vries, P. G. , Lindhoud, S. , Paulusse, J. M. J. , Jonkheijm, P., & Wong, A. S. Y. (2023). Conceptual Modeling Enables Systems Thinking in Sustainable Chemistry and Chemical Engineering. Journal of chemical education, 100(12), 4577-4584. https://doi.org/10.1021/acs.jchemed.3c00337

Li, L. , Baig, M. I. , de Vos, W. M. , & Lindhoud, S. (2023). Preparation of Sodium Carboxymethyl Cellulose-Chitosan Complex Membranes through Sustainable Aqueous Phase Separation. ACS Applied Polymer Materials, 5(3), 1810-1818. https://doi.org/10.1021/acsapm.2c01901

Krishna B, A. , de Vos, W. M. , & Lindhoud, S. (2023). Control over Charge Density by Tuning the Polyelectrolyte Type and Monomer Ratio in Saloplastic-Based Ion-Exchange Membranes. Langmuir, 39(19), 6874-6884. https://doi.org/10.1021/acs.langmuir.3c00497

Lipiński, W. P., Visser, B. S., Robu, I. , Fakhree, M. A. A. , Lindhoud, S. , Claessens, M. M. A. E., & Spruijt, E. (2022). Biomolecular condensates can both accelerate and suppress aggregation of α-synuclein. Science advances, 8(48), Article eabq6495. https://doi.org/10.1126/sciadv.abq6495

Krishna B, A. (2022). Hot-pressed Saloplastics as Sustainable Ion-exchange Membranes (1 ed.). [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036554084

Krishna B, A. , Zwijnenberg, H. J. , Lindhoud, S. , & de Vos, W. M. (2022). Sustainable K⁺/Na⁺ monovalent-selective membranes with hot-pressed PSS-PVA saloplastics. Journal of membrane science, 652, Article 120463. https://doi.org/10.1016/j.memsci.2022.120463

van Lente, J. J. , Baig, M. I. , de Vos, W. M. , & Lindhoud, S. (2022). Biocatalytic membranes through aqueous phase separation. Journal of colloid and interface science, 616, 903-910. https://doi.org/10.1016/j.jcis.2022.02.094

Krishna B, A. , Willott, J. D. , Lindhoud, S. , & de Vos, W. M. (2022). Hot-pressing polyelectrolyte complexes into tunable dense saloplastics. Polymer, 242, Article 124583. https://doi.org/10.1016/j.polymer.2022.124583

van Lente, J. J. (2022). Applications of Polyelectrolyte Complexes for Separation Processes. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036553025

van Lente, J. J. , & Lindhoud, S. (2022). Extraction of Lysozyme from Chicken Albumen Using Polyelectrolyte Complexes. Small, 18(6), Article 2105147. https://doi.org/10.1002/smll.202105147

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Bachelor

Chemical Science Engineering

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