Sabine Siesling, clinical epidemiologist, is professor ‘Outcomes Research and Personalized cancer care’ at the University of Twente and senior researcher at the Netherlands Comprehensive Cancer Organisation (IKNL). She focusses on the effect of interventions, such as care pathways or implementation of new technologies, on the quality, organisation and outcome of cancer care. She tailors care and follow-up using/developing prediction models which are based on data from e.g. the Netherlands Cancer registry. She is board member of the National breast cancer working group (NABON) and the NABON Breast cancer audit and PROMS sections, and the European Initiative on Breast cancer Care-Quality assurance Development group. Moreover, she leads the program on Women’s Health at the University of Twente.  

She has been president of the Netherlands Epidemiological Society.  


  • Medicine and Dentistry

    • Breast Cancer
    • Patient
    • Therapeutic Procedure
    • Survival
    • Cancer Registry
    • Hospital
    • Neoplasm
    • Malignant Neoplasm


Ancillary activities

  • Integraal Kankercentrum Nederland (IKNL)headresearcher


A comparison of treatment allocation and survival between younger and older patients with HER2-overexpressing de novo metastatic breast cancerJournal of geriatric oncology, 15(6), Article 101805 (E-pub ahead of print/First online). Lemij, A., de Glas, N., Kroep, J., Siesling, S., van den Bos, F., Bastiaannet, E., Liefers, G. J. & Portielje, J. outcomes and prognosis of HER2+ invasive breast cancer patients with a DCIS component treated with breast-conserving surgery after neoadjuvant systemic therapyEuropean journal of surgical oncology, 50(9), Article 108465 (E-pub ahead of print/First online). Ploumen, R. A. W., Claassens, E. L., Kooreman, L. F. S., Keymeulen, K., van Kats, M. A. C. E., van Kuijk, S. M. J., Siesling, S., van Nijnatten, T. J. A. & Smidt, M. L. for personalised follow-up in breast cancer: the gap between daily practice and recurrence riskBreast cancer research and treatment, 205, 313-322 (E-pub ahead of print/First online). Voets, M., Hassink, N., Veltman, J., Slump, C. H., Koffijberg, H. & Siesling, S. and communication priorities of patients and healthcare professionals in shared decision making regarding adjuvant systemic breast cancer treatment: A survey studyEuropean journal of oncology nursing, 70, Article 102574 (E-pub ahead of print/First online). Damman, O. C., van Strien-Knippenberg, I. S., Engelhardt, E. G., Determann, D., Bruijne, M. C. D., Siesling, S., Konings, I. R. & Timmermans, D. R. M. breast cancer care within resource limitationsOncologist (E-pub ahead of print/First online). Verhoeven, D., Siesling, S., Allemani, C., Roy, P., Travado, L., Bhoo-Pathy, N., Rhayns, C., Junkermann, H., Nakamura, S., Lasebikan, N. & Tucker, F. Responsiveness of EQ-5D-5L and EORTC QLQ-C30 in Dutch Breast Cancer Patients during the First Year Post-Surgery: A Longitudinal Cohort StudyCancers, 16(11), 1952. Vrancken Peeters, N. J. M. C., van Til, J. A., Huberts, A. S., Siesling, S., Husson, O. & Koppert, L. B. of care for patients with de novo metastatic cancer during the COVID-19 pandemic: A population-based observational studyInternational journal of cancer, 154(10), 1786-1793 (E-pub ahead of print/First online). Slotman, E., Weijzen, F., Fransen, H. P., van Hoeve, J. C., Huijben, A. M. T., Kuip, E. J. M., Jager, A., Kunst, P. W. A., van Laarhoven, H. W. M., Tol, J., Tjan-Heijnen, V. C. G., Raijmakers, N. J. H., van der Linden, Y. M. & Siesling, S. INFLUENCE 3.0 model: updated predictions of locoregional recurrence and contralateral breast cancer, now also suitable for patients treated with neoadjuvant systemic therapy. Research Square Publications. van Maaren, M. C., Hueting, T. A., van Uden, D. J. P., van Hezewijk, M., de Munck, L., Mureau, M. A. M., Seegers, P. A., Voorham, Q. J., Schmidt, M. K., Sonke, G. S., Oudshoorn, C. G. M. & Siesling, S. effectiveness of personalised surveillance and aftercare in breast cancer follow-up: a systematic reviewSupportive care in cancer, 32, Article 323. van Maaren, M. C., van Middelkoop-van Hoeve, J. C., Korevaar, J. C., van Hezewijk, M., Siemerink, E. J. M., Zeillemaker, A. M., Klaassen-Dekker, A., van Uden, D. J. P., Volders, J. H., Drossaert, S. C. H. C. & Siesling, S. in EuropaDie Onkologie, 30(4), 245-256. Arndt, V. & Siesling, S. and Variation in the Use of Radiotherapy in Non-metastatic Rectal Cancer: a 14-year Nationwide Overview from the NetherlandsClinical oncology, 36(4), 221-232. Verrijssen, A.-S. E., Evers, J., van der Sangen, M., Siesling, S., Aarts, M. J., Struikmans, H., Bloemers, M. C. W. M., Burger, J. & Lemmens, V. treatment patterns in the Netherlands: Insights from the Netherlands Cancer Registry. University of Twente. Evers, J. Author Reflections: What Can Prediction Models for Upstaging of DCIS Diagnosed on Biopsy Tell Us About DCIS Surveillance Trials?Annals of surgical oncology, 31(4), 2272-2273. Westenend, P., Meurs, C., van Bekkum, S., van Rosmalen, J., Menke-Pluijmers, M. & Siesling, S. value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancerESMO Open, 9(3), Article 102923. de Boo, L. W., Jóźwiak, K., ter Hoeve, N. D., van Diest, P. J., Opdam, M., Wang, Y., Schmidt, M. K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R. H. T., Kerver, E. D., van Dalen, T., Bins, A. D., Beeker, A., van den Heiligenberg, S. M., de Jong, P. C., Bakker, S. D., … Linn, S. C. support towards optimal intervention for breast cancer patients who experience cancer-related fatigueIn 45th Annual North American Meeting of the Society for Medical Decision Making, Philadelphia, Pennsylvania, United States, 22-25 October 2023, Article 23947 (E-pub ahead of print/First online). Beenhakker, L., Wijlens, K. A. E., Witteveen, A., Bode, C., Siesling, S. & Vollenbroek-Hutten, M. M. R. decision support systems for multidisciplinary team decision-making in patients with solid cancer: Composition of an implementation model based on a scoping reviewCritical Reviews in Oncology/Hematology, 195, Article 104267. Hendriks, M. P., Jager, A., Ebben, K. C. W. J., van Til, J. A. & Siesling, S. outcomes of young, node-negative, chemotherapy-naïve, triple-negative breast cancer patients according to BRCA1 statusBMC Medicine, 22, Article 9 (E-pub ahead of print/First online). Wang, Y., Dackus, G. M. H. E., Rosenberg, E. H., Cornelissen, S., de Boo, L. W., Broeks, A., Brugman, W., Chan, T. W. S., van Diest, P. J., Hauptmann, M., ter Hoeve, N. D., Isaeva, O. I., de Jong, V. M. T., Jóźwiak, K., Kluin, R. J. C., Kok, M., Koop, E., Nederlof, P. M., Opdam, M., … Schmidt, M. K. of the COVID-19 pandemic on the in-hospital diagnostic pathway of breast and colorectal cancer in the Netherlands: A population-based studyCancer medicine, 13(1), Article e6861. Wolfkamp, W., Meijer, J., van Middelkoop-van Hoeve, J. C., van Erning, F., Oei, L.-F., de Hingh, I. H., Veltman, J. & Siesling, S. in potentially inappropriate end-of-life hospital care for cancer patients during the COVID-19 pandemic: A retrospective population-based studyPalliative Medicine, 38(1), 140-149. Slotman, E., Fransen, H. P., van Laarhoven, H. W. M., van den Beuken-van Everdingen, M. H. J., Tjan-Heijnen, V. C. G., Huijben, A. M. T., Jager, A., van Zuylen, L., Kuip, E. J. M., van der Linden, Y. M., Raijmakers, N. J. H. & Siesling, S. use of outcome information in shared decision-making about surveillance after breast cancer. University of Twente. Ankersmid, J. W.

Research profiles


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