EEMCS-EE-BSS

Ciska Heida (PhD) is an Associate Professor in the Biomedical Signals & Systems group. She has a background in Electrical Engineering with a specialization in Biomedical Engineering (MSc 1997) and received her PhD in the field of neurotechnology at the University of Twente in 2002. Her current research interests focus on increasing our understanding of the central mechanisms of human motor control, the pathophysiology underlying movement disorders, and the application of neuromodulation techniques for restoring motor control. Her teaching activities are related to signal analysis of biomedical/clinical data and bioelectromagnetics.

Expertise

  • Neuroscience

    • Parkinson's Disease
    • Tremor
    • Essential Tremor
    • Deep Brain Stimulation
    • Subthalamic Nucleus
  • Medicine and Dentistry

    • Electrical Brain Stimulation
    • Patient
  • Nursing and Health Professions

    • Parkinson Disease

Organisations

How does human neural circuitry control posture and voluntary movements? Insight into the central mechanisms of human motor control and motor disorders such as Parkinson’s disease forms the basis for development of advanced therapies. Deep Brain Stimulation (DBS) and cueing can be used to improve symptoms for Parkinson’s disease patients (e.g. tremor, bradykinesia, rigidity). However, the mechanisms of DBS and cueing are still unclear and especially with DBS side-effects may occur. It is not well known which neuronal elements and pathways are activated or blocked with these treatments, and how the entire neural circuitry responds to the induced activation patterns since there is still limited knowledge of the connections within this network.

With the use of computational models of (part of) the brain networks involved in motor control we study the function of these networks and the effects of neuromodulation on network behaviour. In addition, experimental research including movement tests performed by patients while recording brain activity (LFP, MER, EEG, fNIRS) provide us with information regarding the (patho)physiology, the mechanisms and clinical effects of neuromodulation techniques. Based on these insights we develop new techniques and methods for diagnostic and therapeutic purposes.

Publications

2024
Subthalamic and pallidal neurons are modulated during externally cued movements in Parkinson's diseaseNeurobiology of disease, 190, Article 106384. Tran, S., Heida, T. C., Heijs, J. J. A., Al-Ozzi, T., Sumarac, S., Alanazi, F. I., Kalia, S. K., Hodaie, M., Lozano, A. M., Milosevic, L., Chen, R. & Hutchison, W. D.https://doi.org/10.1016/j.nbd.2023.106384
2022
Closing the loop: Novel quantitative fMRI approach for manipulation of the sensorimotor loop in tremorNeuroImage, 262, Article 119554. Sharifi, S., Luft, F., Boer, L. d., Buijink, A. W. G., Mugge, W., Schouten, A. C., Heida, T., Bour, L. J. & Rootselaar, A. F. v.https://doi.org/10.1016/j.neuroimage.2022.119554Intraoperative Quantification of MDS-UPDRS Tremor Measurements Using 3D Accelerometry: A Pilot StudyJournal of Clinical Medicine, 11, Article 2275. Smid, A., Elting, J. W. J., Dijk, J. M. C. v., Otten, B., Oterdoom, D. L. M., Tamasi, K., Heida, T., Laar, T. v. & Drost, G.https://doi.org/10.3390/jcm11092275Differences in Olivo-Cerebellar Circuit and Cerebellar Network Connectivity in Essential Tremor: a Resting State fMRI StudyCerebellum. Sharifi, S., Buijink, A. W. G., Luft, F., Scheijbeler, E. P., Potters, W. V., van Wingen, G., Heida, T., Bour, L. J. & van Rootselaar, A. F.https://doi.org/10.1007/s12311-022-01486-1
2021
2020

Research profiles

Affiliated study programs

Courses academic year 2023/2024

Courses in the current academic year are added at the moment they are finalised in the Osiris system. Therefore it is possible that the list is not yet complete for the whole academic year.

Courses academic year 2022/2023

INTENSE - Innovative Neurotechnology for Society 

https://www.utwente.nl/en/eemcs/bss/research-projects/intense-project/

PROMP - Personalised-care and Research on Motoric dysfunctioning for patient-specific treatments

https://www.utwente.nl/en/eemcs/bss/research-projects/PROMPT-project-description/ 

Address

University of Twente

Horst Complex (building no. 20), room ZH214
De Horst 2
7522 LW Enschede
Netherlands

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