Before joining the department of Health Technology and Services research in 2020, Xavier performed his doctoral research, "Embracing Uncertainty in Health Technology Assessment", at the Maastricht University Medical Centre+. His research interests are the use of simulation models to evaluate the value of new health care technologies and how to improve the transparency of these simulation models. Currently, Xavier is involved in research projects focusing on the early detection of (risk factors for) cardiovascular diseases. Xavier also teaches the basic principles of (early) health economic evaluations in multiple study programs (Bachelor Health Sciences and Master Biomedical Engineering).


  • Medicine and Dentistry

    • Cost-Effectiveness Analysis
    • Health Care Cost
    • Patient
    • Quality Adjusted Life Year
    • Therapeutic Procedure
    • Cardiovascular Disease
    • Systematic Review
    • Breast Cancer



A Blueprint for Multi-use Disease Modeling in Health Economics: Results from Two Expert-Panel ConsultationsPharmacoEconomics, 42(7), 797-810 (E-pub ahead of print/First online). Wang, J., Pouwels, X., Ramaekers, B., Frederix, G., van Lieshout, C., Hoogenveen, R., Li, X., de Wit, G. A., Joore, M., Koffijberg, H., van Giessen, A., Knies, S. & Feenstra, T. Open Science in Teaching Health Economic ModellingPharmacoEconomics - Open, 8, 347-357 (E-pub ahead of print/First online). Pouwels, X. G. L. V. & Koffijberg, H. of home-based screening of the general population for albuminuria to prevent progression of cardiovascular and kidney diseaseEClinicalMedicine, 68, Article 102414. Pouwels, X. G. L. V., Mil, D. v., Kieneker, L. M., Boersma, C., Etten, R. W. v., Evers-Roeten, B., Heerspink, H. J. L., Hemmelder, M. H., Langelaan, M., Thelen, M., Gansevoort, R. T. & Koffijberg, H. of screening for chronic kidney disease: existing evidence and knowledge gapsClinical Kidney Journal, 17(1), Article sfad254. Mil, D. v., Pouwels, X. G. L. V., Heerspink, H. L. & Gansevoort, R. T.
Can artificial intelligence separate the wheat from the chaff in systematic reviews of health economic articles?Expert Review of Pharmacoeconomics and Outcomes Research, 23(9), 1049-1056. Oude Wolcherink, M. J., Pouwels, X. G. L. V., van Dijk, S. H. B., Doggen, C. J. M. & Koffijberg, H. to "Uncertainty management in regulatory and health technology assessment decision-making on drugs: Guidance of the HTAi-DIA working group"International journal of technology assessment in health care, 39(1), Article e70. Grimm, S. E., Pouwels, X. G. L. V., Ramaekers, B. L. T., Wijnen, B., Grutters, J. & Joore, M. A. of CTC guided chemo- or endocrine therapy in ER+ HER2- metastatic breast cancer – results from a randomized controlled multicenter trial. Berghuis, A. M. S., Koffijberg, H., Pouwels, X. G. L. V., Berger, F., Alix-Panabières, C., Jacot, W., Pierga, J. Y., Bidard, F. C. & IJzerman, M. J. Economic Research Assessing the Value of Early Detection of Cardiovascular Disease: A Systematic ReviewPharmacoEconomics, 41(10), 1183-1203. Wolcherink, M. J. O., Behr, C. M., Pouwels, X. G. L. V., Doggen, C. J. M. & Koffijberg, H. to Open Science principles and practices. Pouwels, X. G. L. V. to R markdown. Zenodo. Pouwels, X.

Research profiles


Visiting address

University of Twente

Technohal (building no. 18), room 3306
Hallenweg 5
7522 NH Enschede

Navigate to location


Scan the QR code or
Download vCard